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Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
Published on: July 28, 2023
WeChat-based manual enhanced guidance in patients with Helicobacter pylori infection
Xiaoye Shi1,2, Zhe Li1,3, Zhenhua Tong4
1Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, Liaoning Province, 110840, China.
Background:
Patients' adherence is important for successful Helicobacter pylori (H. pylori) eradication, and may be improved by WeChat, a popular social networking platform. This study aimed to evaluate patients' adherence, successful H. pylori eradication, and clinical remission under the WeChat-based enhanced guidance.
Methods:
Ninety-nine patients with H. pylori infection, who were treated by a 14-day standard bismuth-containing quadruple therapy (BQT) and received the WeChat-based enhanced guidance, were retrospectively included. Multivariate logistic regression analysis was performed to identify independent predictors of patients' adherence and H. pylori eradication. Odds ratios (ORs) were calculated.
Results:
The rates of good medication adherence, good re-examination adherence, successful H. pylori eradication, and clinical remission were 97.0%, 83.8%, 89.2%, and 89.5%, respectively. Patients with poor re-examination adherence had significantly lower proportions of individual dining (13.3% versus 50.6%, P=0.008) and no smoking during treatment (66.7% versus 92.8%, P=0.012) than those with good re-examination adherence. Both individual dining (OR=0.182, P=0.035) and no smoking during treatment (OR=0.210, P=0.031) were independently associated with good re-examination adherence. Patients with H. pylori eradication failure had significantly higher proportions of poor medication adherence (22.2% versus 1.4%, P=0.030) and living in rural area (44.4% versus 8.1%, P=0.009) than those with H. pylori eradication success. Both poor medication adherence (OR=20.366, P=0.031) and living in rural area (OR=8.944, P=0.010) were independently associated with H. pylori eradication failure.
Conclusion:
There is good medication adherence with satisfactory H. pylori eradication and clinical remission under the WeChat-based enhanced guidance. How to improve re-examination adherence should be further explored.
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