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Updated: Jan 7, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
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The importance of autophagy in multiple myeloma

Martyna Bednarczyk1, Nicola Dąbrowska-Szeja1, Dariusz Łętowski1

  • 1Department of Cancer Prevention, Faculty of Public Health, Silesian Medical University, Katowice, Poland.

Expert Review of Anticancer Therapy
|December 28, 2025
PubMed
Abstract

Insights

Autophagy, a cellular process, plays a complex role in multiple myeloma (MM) development and progression. Targeting autophagy offers potential for novel MM diagnostics and treatments.

Area of Science:

  • Cellular Biology
  • Oncology
  • Immunology

Background:

  • Autophagy is a fundamental cellular process involved in degrading damaged proteins and organelles.
  • Dysregulation of autophagy is implicated in various diseases, including cancer.
  • Previous research highlights the significance of autophagy in cancer pathogenesis.

Purpose of the Study:

  • To review the role of autophagy in the development of multiple myeloma (MM).
  • To explore autophagy mechanisms in MM within the context of UPR, BMME, drug resistance, hypoxia, and DNA repair.
  • To identify potential therapeutic targets within autophagy-related genes and pathways in MM.

Main Methods:

  • Systematic literature search of PubMed and Google Scholar.
  • Analysis of meta-analyses, case-control studies, and observational studies on autophagy in multiple myeloma.
  • Review of current research on autophagy mechanisms and their relevance to MM.

Main Results:

  • Autophagy exhibits a dual role in cancer, potentially promoting or inhibiting carcinogenesis.
  • Autophagy is critical for B cell fate, influencing survival or cell death.
  • Autophagy modulation is discussed concerning UPR, BMME, drug resistance, hypoxia, and DNA repair in MM.

Conclusions:

  • Autophagy gene expression analysis may aid in MM diagnosis and personalized treatment.
  • Modulating autophagy presents a promising therapeutic strategy to limit MM progression and enhance treatment efficacy.
  • Targeting autophagy pathways could lead to novel molecular targeted therapies for MM.
Keywords:
Multiple myelomaautophagybone marrow microenvironmentdrug resistancehematologyplasma cellsunfolded protein response

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