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Sweet Foods Intake and Risk of Pancreatic Diseases: A large cohort study from the UK Biobank
Objectives:
Growing evidence has linked sweet food intake to obesity, diabetes, and mortality, but its association with pancreatic disease remains underexplored.
Methods:
A total of 136 367 participants aged 40-69 y from the UK Biobank were included. Sweet food intake was assessed through dietary questionnaires, and pancreatic disease outcomes were identified using clinical and self-reported data. Multivariable Cox proportional hazards regression models were employed to estimate the hazard ratios (HRs) for pancreatic disease risk across quartiles of sweet food intake.
Results:
During a median (interquartile range) follow-up of 11.6 (11.2-12.4) y, 348 pancreatic cancer events, 527 acute pancreatitis events, and 319 chronic pancreatitis events occurred. Higher sweet food intake was associated with an increased risk of chronic pancreatitis (HRQuartile 4 vs. Quartile 1: 1.87; 95% confidence interval [CI], 1.32-2.64; Ptrend < 0.001) but not with pancreatic cancer (HRQuartile 4 vs. Quartile 1: 1.11; 95% CI, 0.80-1.53; Ptrend = 0.60) or acute pancreatitis (HRQuartile 4 vs. Quartile 1: 0.95; 95% CI, 0.72-1.23; Ptrend = 0.65).
Conclusions:
Findings from this cohort study suggest that lower intake of sweet foods may reduce the risk of chronic pancreatitis.
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