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Nutritional immunology in lifespan.

Maryam Fallah1, Fatemeh Naeini2, Fatemeh Sadat Fahimzad2

  • 1Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Experimental Gerontology
|December 28, 2025
PubMed
Summary
This summary is machine-generated.

Immunonutrition, using vitamins and minerals, may enhance immune function and longevity by combating oxidative stress and inflammation. Further research is needed to confirm these effects on aging and lifespan.

Keywords:
AdultsImmune systemImmunonutritionOxi-inflamm-aging theory

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Area of Science:

  • Nutritional Immunology
  • Gerontology
  • Oxidative Stress Research

Background:

  • Immunonutrition involves dietary interventions to boost immune function.
  • Key nutrients include amino acids, vitamins, minerals, and flavonoids.
  • The oxi-inflamm-aging theory links diet, immunity, and lifespan via antioxidant and anti-inflammatory pathways.

Purpose of the Study:

  • To investigate how immunonutrients modulate immune activity and lifespan.
  • To explore the antioxidant and anti-inflammatory mechanisms involved.
  • To examine the role of specific nutrients like Vitamin C, E, D, Zinc, Selenium, and Flavonoids in aging.

Main Methods:

  • Review and theoretical examination of existing research on immunonutrients and aging.
  • Analysis of the oxi-inflamm-aging theory.
  • Exploration of molecular pathways influenced by specific nutrients (e.g., P21 signaling, SKN-1 gene expression).

Main Results:

  • Vitamin C may increase lifespan if consumed early.
  • Vitamin E can reduce disease mortality by inhibiting oxidative damage and activating anti-cancer pathways.
  • Vitamin D may reduce aging by influencing stress response genes and protein aggregation.
  • Zinc regulates immune cell activity.
  • Selenium improves cellular redox homeostasis and immune function.
  • Flavonoids protect against aging phenotypes by supporting neuronal and metabolic health.

Conclusions:

  • Specific immunonutrients show potential in mitigating aging processes and enhancing immune function.
  • These effects are linked to antioxidant, anti-inflammatory, and cellular protection mechanisms.
  • Further comprehensive studies are required to validate these findings and their clinical implications.