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Updated: Jan 7, 2026
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
Published on: May 2, 2011
A Novel Prophylaxis Strategy Using Ecotin as A Promising Adjuvant for Fc-RBD Fusion Protein Vaccine of SARS-CoV-2
Yakun Sun1, Rui Zheng1, Deyu Li1
1State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Abstract:
Ecotin, a metabolite secreted by gut microbiota, improved the survival of virus-infected mice when administered via standalone injection. Vaccination of mice with a formulation of recombinant Ecotin and RBD-Fc antigen elicited an earlier production of IgG antibodies, accompanied by a marked increase in the number of CD3+ T cells in mouse lung tissues.
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