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Safety and Efficacy of Different Sedation Regimens in Pediatric Diagnostic Gastroscopy: A Retrospective Controlled

Qin Chen1, Jiejie Wang1, Caiyu Hu1

  • 1Department of Pediatrics, Nantong First People's Hospital (Affiliated Hospital 2 of Nantong University), Nantong, China.

Clinical Pediatrics
|December 29, 2025
PubMed

Insights

Propofol monotherapy is a safe and effective sedation method for pediatric gastroscopy, offering faster recovery and better vital sign stability compared to midazolam and propofol combinations.

Area of Science:

  • Pediatric Gastroenterology
  • Anesthesiology
  • Clinical Pharmacology

Background:

  • Sedation is crucial for pediatric diagnostic gastroscopy.
  • Current protocols often involve combinations of sedatives.
  • Optimizing sedation strategies is essential for patient safety and procedural efficiency.

Purpose of the Study:

  • To compare the safety and efficacy of propofol monotherapy versus midazolam combined with propofol for pediatric gastroscopy.
  • To provide evidence for refining clinical sedation protocols in pediatric endoscopy.

Main Methods:

  • Retrospective analysis of 162 children (3-14 years) undergoing gastroscopy.
  • Two groups: propofol monotherapy (n=78) and midazolam-propofol combination (n=84).
  • Comparison of baseline characteristics, sedation efficacy, recovery, vital signs, adverse events, and procedure times.

Main Results:

  • Propofol monotherapy demonstrated rapid recovery and minimal impact on vital signs.
  • The propofol group showed improved turnover efficiency.
  • No significant differences in overall safety were highlighted, but recovery was faster with propofol.

Conclusions:

  • Propofol monotherapy is a potentially superior sedation strategy for pediatric diagnostic gastroscopy.
  • It offers advantages in recovery speed and hemodynamic stability.
  • Supports optimization of sedation protocols towards propofol monotherapy in this population.

Keywords:
efficacygastroscopymidazolampediatricspropofolsafetysedation

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