Related Experiment Video

Updated: Jan 7, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.9K

Research Trends and Insights Regarding MicroRNAs in Psoriasis: A Comprehensive Analysis

Ismail Örs1, Nur Cihan Cosansu2, Berna Solak3

  • 1Dermatology, Meram State Hospital, Konya, TUR.

Cureus
|December 29, 2025
PubMed

Insights

MicroRNAs (miRNAs) are key in psoriasis research, with studies growing and shifting towards translational applications. This analysis maps the research landscape, identifying key miRNA hubs for biomarker and clinical use.

Area of Science:

  • Dermatology and Bioinformatics
  • Focuses on the intersection of microRNA research and psoriasis, utilizing bibliometric and network analysis for informatics and translational insights.

Background:

  • MicroRNAs (miRNAs) play a crucial role in regulating biological processes relevant to psoriasis.
  • The global research landscape concerning miRNAs in psoriasis lacks a systematic informatics and translational mapping.
  • Understanding this landscape is vital for advancing psoriasis diagnostics and therapeutics.

Purpose of the Study:

  • To systematically map the global research landscape of miRNAs in psoriasis from an informatics and translational perspective.
  • To identify key themes, influential publications, and emerging trends in miRNA research for psoriasis.
  • To highlight potential miRNA biomarkers and therapeutic targets for psoriasis.

Main Methods:

  • Bibliometric and network analyses were conducted on publications from the Web of Science Core Collection (2003-2024).
  • VOSviewer and the bibliometrix package in R were used for co-authorship, co-occurrence, and citation network construction.
  • STRING database was utilized to summarize protein-protein and miRNA-target interactions.

Main Results:

  • Identified 449 publications showing a 13.8% annual growth rate and high citation impact.
  • Thematic mapping revealed core themes (psoriasis, inflammation), motor themes (miR-146a-5p, exosomes), and emerging terms (STAT3, adalimumab).
  • Key regulatory hubs (STAT3, PTEN, TRAF6) involved in inflammatory and proliferative pathways were identified, with translational tags linking biomarkers and drug development.

Conclusions:

  • Research on miRNAs in psoriasis demonstrates sustained growth and a significant shift towards translational applications.
  • The identified miRNA hubs and thematic trends provide a foundation for biomarker panel selection and clinical trial design.
  • This evidence map can inform clinical decision support for psoriasis management and therapeutic strategies.
Keywords:
biomarkersinflammationkeratinocytesmicrornasmirnapsoriasis

More Related Videos

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion07:54

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion

Published on: August 29, 2018

9.0K
Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.5K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.8K