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Updated: Jun 28, 2026

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
LONG-TERM FOLLOW-UP OF FUNCTIONING AND LIFE SATISFACTION AFTER MODERATE TO SEVERE TBI - AN EXPLORATORY COHORT STUDY
Marianne Lannsjö1, Jörgen Borg2, Charlotta VON Seth3
1Section of Rehabilitation Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Objective:
To examine the long-term outcomes after moderate to severe traumatic brain injury with diffuse axonal injury.
Design:
A follow-up study of a regional cohort with a mean follow-up period of 5 years post-injury.
Subjects:
Thirty-four participants were recruited from a regional neurointensive care unit. Inclusion criteria were age 16-65 years, a Glasgow Coma Scale score of 3-12, and radiologically confirmed diffuse axonal injury.
Methods:
Follow-up assessments conducted at least 1 year post-injury included global outcome measured by the Glasgow Outcome Scale Extended, activities of daily living assessed with the Barthel Index, and life satisfaction evaluated using the LiSat checklist.
Results:
More than two-thirds of participants regained independence, and approximately half returned to work or studies. A higher diffuse axonal injury stage was associated with a lower likelihood of returning to work or studies. Over half of respondents reported being satisfied or very satisfied with "life as a whole." Return to work or study was significantly associated with life satisfaction, and there was a trend toward higher satisfaction among those living with a partner.
Conclusion:
These findings confirm and extend observations from previous studies, emphasizing key areas for rehabilitation and long-term outcome after moderate to severe traumatic brain injury with diffuse axonal injury.
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