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Modified Chitosan With Oxidized Nanocellulose and Cerium-Containing Mesoporous Bioactive Glass Nanoparticles:
Rizos Evangelos Bikiaris1,2, Nikolaos Iosif Matschek1, Ioanna Koumentakou2
1Laboratory of Polymer and Colors Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|December 29, 2025
Summary
Novel nanocomposite hemostatic sponges, combining modified chitosan, gelatin, and bioactive glass nanoparticles, show excellent biocompatibility and hemostatic properties. These advanced wound dressings offer significant potential for emergency trauma care.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomedical Engineering
Background:
- Hemostatic agents are crucial for managing bleeding in trauma.
- Chitosan and gelatin are widely used biomaterials for wound healing.
- Bioactive glass nanoparticles offer enhanced therapeutic properties.
Purpose of the Study:
- To develop and characterize novel nanocomposite hemostatic sponges.
- To evaluate the physicochemical properties, biocompatibility, and hemostatic efficacy of the sponges.
- To explore the potential of these sponges for emergency trauma treatment.
Main Methods:
- Synthesis of modified chitosan via Schiff base crosslinking.
- Incorporation of gelatin and mesoporous bioactive glass nanoparticles (MBGNPs), with and without Cerium (Ce).
- Characterization using FTIR, SEM, and assessment of swelling, mechanical properties, cell viability, and blood clotting time.
Main Results:
- Sponges exhibited a porous structure and desirable physicochemical properties.
- Exceptional water sorption capacity observed at pH 5.6 (nearly 5000%).
- High in vitro cell viability (>120% for MBGNPs-Ce) and significant enhancement of blood clotting time and platelet clot formation were confirmed.
Conclusions:
- The developed nanocomposite hemostatic sponges demonstrate excellent biocompatibility and potent hemostatic capabilities.
- The incorporation of MBGNPs, particularly MBGNPs-Ce, significantly improves hemostatic performance.
- These sponges represent promising advanced wound dressings for emergency trauma management in diverse settings.
