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Tempeh Extract and HSC-3 Cell Migration: An In Vitro Study.

Rahmi Amtha1, Shirley Tjhie2, Firstine Kelsi Hartanto1

  • 1Department of Oral Medicine, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.

Asian Pacific Journal of Cancer Prevention : APJCP
|December 29, 2025
PubMed
Summary

Tempeh extract did not inhibit HSC-3 cell migration at tested concentrations. The 50 μg/mL concentration showed increased migration after 24 hours, suggesting no inhibitory effect for this natural compound.

Keywords:
HSC-3Tempeh extractmigrationoral squamous cell carcinoma

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Area of Science:

  • Biotechnology and Cell Biology
  • Natural Product Research

Background:

  • HSC-3 cells are a human oral cancer cell line.
  • Tempeh extract is derived from fermented soybeans, known for potential bioactive compounds.

Purpose of the Study:

  • To evaluate the effect of varying concentrations of tempeh extract on HSC-3 cell migration.
  • To compare the migration capacity of HSC-3 cells after treatment with tempeh extract dissolved in ethanol or water.

Main Methods:

  • HSC-3 cells were treated with tempeh extract (25-400 μg/mL) in 70% ethanol or water.
  • Cell migration was assessed using a scratch assay at 6 and 24 hours.
  • Statistical analysis included ANOVA and Kruskal-Wallis tests.

Main Results:

  • No significant difference in cell migration was observed at 6 hours for either solvent.
  • After 24 hours, the 50 μg/mL tempeh extract group exhibited a larger scratch area compared to other concentrations (p<0.033).
  • Tempeh extract did not demonstrate an inhibitory effect on HSC-3 cell migration.

Conclusions:

  • Tempeh extract, particularly in water, did not inhibit HSC-3 cell migration compared to doxorubicin.
  • Higher concentrations of tempeh extract may be required to investigate potential inhibitory effects.
  • Further research is warranted to explore the anti-migratory potential of tempeh extract.