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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
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Mortality in neovascular glaucoma
Kirstyn C Taylor1, Sakshi Shiromani2, Avital L Okrent Smolar3
1Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Indian Journal of Ophthalmology
|December 29, 2025
Summary
Neovascular glaucoma (NVG) increases mortality risk, particularly with advancing age and central retinal artery occlusion (CRAO). Aggressive management of underlying conditions is crucial for patients with NVG.
Area of Science:
- Ophthalmology
- Public Health
Background:
- Neovascular glaucoma (NVG) is a severe secondary glaucoma characterized by neovascularization of the iris and anterior chamber angle.
- NVG is often associated with underlying systemic or ocular conditions, impacting patient prognosis and survival.
Purpose of the Study:
- To investigate the mortality rates in patients diagnosed with neovascular glaucoma (NVG).
- To identify the underlying etiologies of NVG and their association with mortality.
- To determine the relationship between NVG and specific causes of death.
Main Methods:
- Retrospective cohort study including 210 patients with NVG.
- Survival analysis performed on 132 patients with a defined NVG onset date.
- Data collected on demographics, etiology, and medical conditions; mortality ascertained via CDC National Death Index.
Main Results:
- 32% of the 210 subjects were deceased by December 31, 2021.
- Proliferative diabetic retinopathy (PDR) was the most common etiology (57%), followed by central retinal vein occlusion (CRVO) (29%).
- Older age and central retinal artery occlusion (CRAO) were significant predictors of poorer survival (HR 1.03 and 4.63, respectively).
Conclusions:
- Increasing age and NVG secondary to CRAO are key predictors of increased mortality.
- Effective management of systemic conditions contributing to NVG is essential to reduce early mortality.
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