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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: Jan 7, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Mortality in neovascular glaucoma.

Kirstyn C Taylor1, Sakshi Shiromani2, Avital L Okrent Smolar3

  • 1Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Indian Journal of Ophthalmology
|December 29, 2025
PubMed
Summary
This summary is machine-generated.

Neovascular glaucoma (NVG) increases mortality risk, particularly with advancing age and central retinal artery occlusion (CRAO). Aggressive management of underlying conditions is crucial for patients with NVG.

Keywords:
Mortalityneovascular glaucomasurvival

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Area of Science:

  • Ophthalmology
  • Public Health

Background:

  • Neovascular glaucoma (NVG) is a severe secondary glaucoma characterized by neovascularization of the iris and anterior chamber angle.
  • NVG is often associated with underlying systemic or ocular conditions, impacting patient prognosis and survival.

Purpose of the Study:

  • To investigate the mortality rates in patients diagnosed with neovascular glaucoma (NVG).
  • To identify the underlying etiologies of NVG and their association with mortality.
  • To determine the relationship between NVG and specific causes of death.

Main Methods:

  • Retrospective cohort study including 210 patients with NVG.
  • Survival analysis performed on 132 patients with a defined NVG onset date.
  • Data collected on demographics, etiology, and medical conditions; mortality ascertained via CDC National Death Index.

Main Results:

  • 32% of the 210 subjects were deceased by December 31, 2021.
  • Proliferative diabetic retinopathy (PDR) was the most common etiology (57%), followed by central retinal vein occlusion (CRVO) (29%).
  • Older age and central retinal artery occlusion (CRAO) were significant predictors of poorer survival (HR 1.03 and 4.63, respectively).

Conclusions:

  • Increasing age and NVG secondary to CRAO are key predictors of increased mortality.
  • Effective management of systemic conditions contributing to NVG is essential to reduce early mortality.