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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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3D Printed Patient-Specific Resorbable Bone Scaffolds for Alveolar Bone Regeneration.

Puneet Wadhwa1, Ho-Kyung Lim2, Hyon-Seok Jang3

  • 1Department of Dentistry, Korea University Graduate School, Medicine, Seoul, 02841, Republic of Korea.

Tissue Engineering and Regenerative Medicine
|December 29, 2025
PubMed
Summary

Three-dimensional (3D) printed biodegradable scaffolds offer precise reconstruction for alveolar bone loss, improving oral rehabilitation outcomes. These patient-specific implants show significant promise in maxillofacial surgery.

Keywords:
3D printingAlveolar bone regenerationBiodegradable materialsBone tissue engineeringCADCBCTPatient-specific scaffolds

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Alveolar bone loss presents significant challenges in oral rehabilitation and implant dentistry.
  • Traditional grafting methods have limitations including resorption and immune incompatibility.
  • Advances in 3D printing enable patient-specific biodegradable scaffolds for defect reconstruction.

Purpose of the Study:

  • To review preclinical and clinical studies on biodegradable 3D printed scaffolds for alveolar bone regeneration.
  • To summarize the materials, applications, and future directions in this field.

Main Methods:

  • Systematic literature search of PubMed, Scopus, and Google Scholar.
  • Focus on studies investigating 3D printed scaffolds for alveolar bone regeneration.
  • Analysis of material properties, clinical applications, and emerging strategies.

Main Results:

  • Various materials like polymers (PLA, PCL, PLGA), ceramics (hydroxyapatite), and hydrogels are used.
  • Composite scaffolds show enhanced osteogenic potential.
  • Clinical applications include ridge preservation, guided bone regeneration, and implant site reconstruction.
  • Bioinks with stem cells and growth factors improve scaffold properties.

Conclusions:

  • 3D printed patient-specific biodegradable scaffolds are a promising alternative to conventional grafting.
  • They offer precise defect reconstruction and improved biological integration.
  • Further optimization of materials and vascularization is key for clinical success.