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Updated: Jan 7, 2026
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
β-Galactosidase-Cleavable Polymeric Senotherapeutics for Protein-Binding Photodynamic Senolysis
Nawab Ali1, Wenlong Huang1, Jia Tian1
1Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Researchers developed PG@FBC, a novel senotherapeutic that precisely targets and eliminates senescent cells (SnCs) using photodynamic therapy. This approach enables real-time imaging and controlled drug release for treating age-related diseases.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Gerontology
Background:
- Senescent cells (SnCs) accumulate with age, contributing to age-related dysfunction.
- Current senolytic strategies lack precision, broad-spectrum control, and real-time monitoring.
- Targeting SnCs is a promising therapeutic strategy for age-related pathologies.
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