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Hydrogen Sulfide in Adipose Tissue Biology
Antonia Katsouda1, Andreas Papapetropoulos2,3
1Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Handbook of Experimental Pharmacology
|December 30, 2025
Summary
Sulfide, a key signaling molecule, regulates adipose tissue homeostasis and metabolism. Modulating sulfide levels offers a promising therapeutic strategy for obesity and metabolic disorders.
Area of Science:
- Physiology
- Biochemistry
- Metabolic Science
Background:
- Sulfide acts as a crucial signaling molecule in various physiological and pathological processes.
- Adipose tissue homeostasis is significantly influenced by sulfide signaling.
- Dysregulation of sulfide in adipose tissue is linked to obesity and metabolic disorders.
Purpose of the Study:
- To comprehensively review the role of sulfide in adipose tissue biology and physiology.
- To emphasize the implications of sulfide signaling in obesity prevention and treatment.
Main Methods:
- Literature review of current research on sulfide and adipose tissue.
- Analysis of studies investigating sulfide's role in adipogenesis, lipogenesis, and metabolism.
- Evaluation of therapeutic strategies targeting sulfide levels.
Main Results:
- Sulfide is a key regulator of adipose tissue functions including adipogenesis, lipogenesis, and glucose/lipid metabolism.
- Evidence links dysregulated sulfide signaling in adipose tissue to obesity and metabolic diseases.
- Pharmacological targeting of sulfide levels shows potential for metabolic health improvement.
Conclusions:
- Sulfide plays a vital role in adipose tissue physiology and metabolic regulation.
- Targeting sulfide signaling presents a promising therapeutic avenue for obesity and related metabolic disorders.
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