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Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress.

Kyung-A Byun1,2, Chang Hu Choi3, Seyeon Oh2,4

  • 1Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.

Antioxidants (Basel, Switzerland)
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Fermented yeast complex extract (FYCE) promotes hair regrowth by reducing oxidative stress and inflammation. This bioactive ingredient activates antioxidant pathways and inhibits inflammatory signals, supporting hair follicle regeneration and increasing hair count.

Keywords:
fermented yeast complex extracthair regrowthoxidative stress

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Area of Science:

  • Dermatology and Hair Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Hair growth relies on a cycle regulated by dermal papilla cells (DPCs), but oxidative stress and inflammation disrupt this process.
  • Fermented yeast complex extract (FYCE), rich in antioxidants like GABA, offers potential for mitigating these disruptions.

Purpose of the Study:

  • To investigate the efficacy of FYCE in promoting hair regrowth.
  • To elucidate FYCE's mechanism of action on oxidative stress and inflammatory pathways in DPCs.

Main Methods:

  • Evaluating FYCE's effects on NRF2, NF-κB, and NLRP3 inflammasome in hydrogen peroxide-treated DPCs.
  • Assessing FYCE's impact on growth factors (IGF-1, Wnt10b, Wnt3a) and β-catenin stabilization.
  • Examining FYCE's effects on hair follicle number and anagen phase in shaved animal skin models.

Main Results:

  • FYCE significantly upregulated NRF2 (3.2-fold) and IGF-1 (5.4-fold), while downregulating NF-κB (0.6-fold) and NLRP3 inflammasome components.
  • FYCE increased Wnt10b (1.8-fold), Wnt3a (2.9-fold), and stabilized β-catenin (2.8-fold).
  • In vivo studies showed FYCE increased hair follicle number (1.6-fold) and promoted the anagen phase (3.0-fold).

Conclusions:

  • FYCE promotes hair regrowth by modulating antioxidative and anti-inflammatory pathways.
  • FYCE's mechanism involves NRF2 activation, NF-κB inhibition, and NLRP3 inflammasome downregulation.
  • FYCE shows promise as a therapeutic agent for hair loss prevention and reversal.