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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

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Sitagliptin Alleviates Radiation-Induced Kidney and Testis Degeneration in Rats.

Huseyin Celik¹, Oztun Temelli², Onural Ozhan³

¹Department of Urology, Faculty of Medicine, Inonu University, Malatya 44100, Türkiye.

|December 30, 2025

Summary

Sitagliptin, an anti-inflammatory drug, can mitigate radiation-induced tissue damage in kidneys and testes. Administering sitagliptin after radiation therapy showed better protective effects, particularly in kidney tissue.

Keywords:

apoptosis histopathology oxidative stress radiation sitagliptin

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Area of Science:

Radiology and Radiation Oncology
Pharmacology
Cell Biology

Background:

Radiotherapy often causes tissue degeneration, a significant clinical challenge.
Sitagliptin's anti-inflammatory and antioxidant properties were investigated for mitigating radiation damage.
Kidney and testis tissues were the focus for evaluating sitagliptin's protective effects.

Purpose of the Study:

To evaluate sitagliptin's efficacy in preventing radiation-induced cellular degeneration in kidney and testis tissues.
To compare the protective effects of sitagliptin administered before versus after radiation exposure.

Main Methods:

Wistar albino rats were grouped into control, radiation (RT), RT + sitagliptin (RT+SGT), and SGT+RT.
Radiation dose was 8 Gy, with sitagliptin administered orally at 10 mg/kg for 14 days.
Histological and biochemical analyses assessed tissue damage and antioxidant parameters.

Main Results:

Radiation induced significant oxidative stress and degenerative changes in kidney and testis tissues.
Sitagliptin partially restored antioxidant parameters in the kidney and reduced MDA levels in the testis.
Sitagliptin treatment attenuated radiation-induced histological damage and restored VEGF expression, with post-radiation administration showing superior kidney protection.

Conclusions:

Sitagliptin demonstrates potential in attenuating radiation-induced degenerative effects.
Administering sitagliptin after radiotherapy yielded significantly better protective outcomes, especially for kidney tissue.
Sitagliptin represents a promising therapeutic agent for managing radiotherapy side effects.