Related Experiment Video

Updated: Jan 7, 2026

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
10:25

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

606

Complexes Formed by the K63-Specific Deubiquitinating Enzyme BRCC36: New Promising Therapeutic Targets in Human

Xinyu Zhang1,2, Xiaodong Pang1, Yili Chen1

  • 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Biomolecules
|December 30, 2025
PubMed

Insights

BRCC36, a deubiquitinating enzyme, forms complexes like BRISC and BRCA1-A to regulate signaling and DNA repair. Its dysregulation is implicated in diseases, highlighting its therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • BRCC36 is a metalloenzyme with unique deubiquitinating functions.
  • It requires complex assembly for activity, specifically cleaving K63-linked polyubiquitin chains.
  • BRCC36 participates in vital cellular processes through its complexes, BRISC and BRCA1-A.

Purpose of the Study:

  • To provide a comprehensive overview of BRCC36 localization, assembly, mutations, and functions.
  • To review recent research on BRCC36 in various diseases.
  • To explore BRCC36's potential as a therapeutic target.

Main Methods:

  • Literature review of BRCC36 research.
  • Analysis of BRCC36 complex formation and function.
  • Examination of BRCC36's role in disease pathogenesis.

Main Results:

  • BRCC36 forms the BRISC complex in the cytoplasm, regulating signaling pathways via K63-linked ubiquitination.
  • BRCC36 forms the BRCA1-A complex in the nucleolus, aiding DNA damage repair.
  • BRCC36's involvement in inflammation, mitosis, hematopoiesis, and DNA repair is highlighted.

Conclusions:

  • The ubiquitin system, especially deubiquitinating enzymes like BRCC36, is crucial in disease initiation and progression.
  • BRCC36 and its complexes are key regulators of fundamental biological processes.
  • BRCC36 presents a promising therapeutic target for various diseases.

Keywords:
BRCA1BRCC36BRISCDeubiquitinationSHMT2

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