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Optimized Extraction Process of Fu Brick Tea Polysaccharides Using Ultrasound-Assisted Enzymatic Strategy and Their
Gaolong Zuo1,2, Yanyan Yao1,3, Yujie Shen1,4
1Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, P. R. China.
Journal of Agricultural and Food Chemistry
|June 16, 2026
Summary
Fu brick tea polysaccharides (FBTPs) with unique structures boost immunity by reshaping gut microbiota. This study clarifies FBTPs
Area of Science:
- Immunology
- Microbiology
- Food Science
Background:
- Fu brick tea polysaccharides (FBTPs) immunomodulatory mechanisms are unclear.
- Structure-bioactivity relationships and gut microbiota involvement need investigation.
Purpose of the Study:
- Investigate structurally distinct FBTPs using ultrasound-assisted enzymatic extraction (UAEPS).
- Elucidate the role of gut microbiota in FBTPs' immunomodulatory effects.
Main Methods:
- Optimized ultrasound-assisted enzymatic extraction for FBTPs (UAEPS).
- Characterization of UAEPS structural features (molecular weight, carbohydrate content).
- In vitro bioactivity assays (antioxidant, anti-inflammatory, cytoprotective).
- Immunosuppressed mouse model studies.
- Fecal microbiota transplantation experiments.
Main Results:
- UAEPS showed unique structural features compared to traditional methods (HWEPS).
- UAEPS demonstrated potent in vitro antioxidant, anti-inflammatory, and cytoprotective activities.
- In vivo, UAEPS restored immune homeostasis, reduced organ damage, and enriched *Lactobacillus* in the gut microbiota.
- Fecal microbiota transplantation confirmed the causal role of gut microbiota in mediating FBTPs' effects.
Conclusions:
- Structurally distinct UAEPS possess significant immunomodulatory properties.
- Gut microbiota remodeling is the primary mechanism underlying FBTPs' immune-boosting effects.
- UAEPS holds potential as a functional food ingredient for immune health.