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Antibacterial Effect of Cannabinoids on Bacteria Associated with Persistent Endodontic Infections

Cassandra Wieczerza1, Haoyan Zhai2, Mazin Askar1

  • 1Endodontic Program, Division of Graduate Education, School of Dentistry, University of Detroit Mercy, Detroit, MI 48208, USA.

International Journal of Molecular Sciences
|December 30, 2025
PubMed
Summary

Cannabinoids like CBD, CBN, and THC show antibacterial effects against common endodontic bacteria, Enterococcus faecalis and Streptococcus mutans, in both planktonic and biofilm forms. However, they were not effective against Fusobacterium nucleatum at tested concentrations.

Keywords:
CBDCBNEnterococcus faecalisFusobacterium nucleatumStreptococcus mutansTHCcannabinoidspersistent endodontic infection

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