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Orchestrating HFpEF: How Noncoding RNAs Drive Pathophysiology and Phenotypic Outcomes
Angeliki Alifragki1, Vasiliki Katsi2, Konstantinos Fragkiadakis1
1School of Medicine, University of Crete, 700 13 Iraklion, Greece.
International Journal of Molecular Sciences
|December 30, 2025
Summary
Heart Failure with Preserved Ejection Fraction (HFpEF) involves complex mechanisms regulated by noncoding RNAs (ncRNAs). These ncRNAs show potential as diagnostic biomarkers and therapeutic targets for personalized HFpEF treatments.
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Genetics
Background:
- Heart Failure with Preserved Ejection Fraction (HFpEF) is a growing public health concern.
- HFpEF pathogenesis involves complex, interconnected mechanisms like diastolic dysfunction, fibrosis, and inflammation.
- Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (LncRNAs), are key regulators of these pathways.
Purpose of the Study:
- To review the main pathophysiological mechanisms of HFpEF.
- To highlight extensively studied ncRNAs involved in HFpEF.
- To discuss the potential of ncRNAs as biomarkers and therapeutic targets for HFpEF.
Main Methods:
- Literature review of pathophysiological mechanisms in HFpEF.
- Identification and summary of key noncoding RNAs (ncRNAs) implicated in HFpEF.
- Analysis of current research on ncRNA roles in HFpEF diagnosis, prognosis, and therapy.
Main Results:
- Several ncRNAs are critically involved in regulating cellular and molecular pathways in HFpEF.
- Specific ncRNAs demonstrate potential as biomarkers for HFpEF diagnosis and prognosis.
- ncRNAs are emerging as promising therapeutic targets for HFpEF.
Conclusions:
- ncRNAs play a significant role in HFpEF pathophysiology.
- ncRNAs offer potential for improved HFpEF diagnosis and prognosis.
- Targeting ncRNAs may lead to novel, personalized therapeutic strategies for HFpEF.
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