Comment on Chu et al. Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective. Int. J. Mol. Sci. 2025,

Keith Fluegge1, Kyle Fluegge1

  • 1Institute of Health and Environmental Research (IHER), Columbus, OH 43216, USA.

Insights

Acetaminophen use during pregnancy is linked to autism risk in children. Leucovorin is suggested as a potential treatment for autism spectrum disorder (ASD).

Area of Science:

  • Neurodevelopmental disorders
  • Perinatal pharmacology

Background:

  • Acetaminophen (paracetamol) is a widely used analgesic and antipyretic.
  • Emerging evidence suggests a potential association between prenatal acetaminophen exposure and neurodevelopmental outcomes.
  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction and communication.

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