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Comment on Chu et al. Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective. Int. J. Mol. Sci. 2025,
1Institute of Health and Environmental Research (IHER), Columbus, OH 43216, USA.
Insights
Acetaminophen use during pregnancy is linked to autism risk in children. Leucovorin is suggested as a potential treatment for autism spectrum disorder (ASD).
Area of Science:
- Neurodevelopmental disorders
- Perinatal pharmacology
Background:
- Acetaminophen (paracetamol) is a widely used analgesic and antipyretic.
- Emerging evidence suggests a potential association between prenatal acetaminophen exposure and neurodevelopmental outcomes.
- Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction and communication.
Abstract:
The United States Food and Drug Administration (FDA) has now linked acetaminophen use in pregnancy to risk of offspring autism and has recommended leucovorin as a possible therapeutic for ASD [...].
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