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Updated: Jan 7, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

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HPV-Driven Immune Evasion in Cervical Cancer: Transcriptomic Identification of Downregulated Hub Genes and Suppressed

Sana Ismael Ameen1, Mahla Masoudi2, Hossein Azizi2

  • 1Department of Gynecology and Obstetrics, Faculty of General Medicine, Koya University, Koya 44023, Kurdistan Region, Iraq.

International Journal of Molecular Sciences
|December 30, 2025
PubMed

Insights

Human Papillomavirus (HPV) infection drives cervical cancer through gene expression changes impacting the tumor microenvironment. Key immune-related genes are altered, affecting immune cell patterns and potentially offering new therapeutic targets.

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Cervical cancer progression is linked to Human Papillomavirus (HPV) infection and tumor microenvironment alterations.
  • Understanding HPV-induced immune evasion mechanisms is vital for effective cervical cancer therapies.

Purpose of the Study:

  • To identify differentially expressed genes (DEGs) in HPV-positive versus HPV-negative cervical cancer.
  • To explore the role of these DEGs in immune evasion and identify potential therapeutic targets.

Main Methods:

  • Transcriptomic analysis of three independent cervical cancer datasets (GSE127265, GSE166466, GSE218460).
  • Construction of protein-protein interaction networks using Cytoscape and STRING.
  • Assessment of immune infiltration using the TIMER database and pathway enrichment analysis.

Main Results:

  • Identified 572 common DEGs between tumor and normal tissues, with distinct profiles in HPV-positive samples.
  • Downregulated hub genes were linked to immune regulation and receptor tyrosine kinase signaling.
  • Observed altered dendritic cell and T cell infiltration, implicating HPV in immune modulation and impaired leukocyte transendothelial migration.

Conclusions:

  • Immune-related hub genes play a critical role in HPV-driven cervical cancer progression.
  • Findings suggest potential therapeutic strategies targeting HPV-induced immune suppression.
Keywords:
HPV-driven cervical cancerimmune evasionimmune modulationleukocyte transendothelial migration pathwaytranscriptomic analysis

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