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Personalized Supplementation Is Associated with Reduced Inflammatory Biomarkers: A 12-Week Observational Study.

Eliza Roeth1, Madeline Morris1, Asher P Reynolds1

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Life (Basel, Switzerland)
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A 12-week personalized supplementation program significantly reduced key inflammation markers like C-reactive protein (CRP) and homocysteine. This precision health approach shows promise for managing systemic inflammation and immune dysregulation.

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Area of Science:

  • Biochemistry
  • Immunology
  • Endocrinology

Background:

  • Chronic low-grade inflammation is linked to cardiovascular disease, metabolic dysfunction, autoimmune disorders, and cognitive decline.
  • Blood biomarkers like C-reactive protein (CRP), ferritin, homocysteine, white blood cell (WBC) count, and anti-thyroid peroxidase (anti-TPO) antibodies are crucial for monitoring systemic inflammation.

Purpose of the Study:

  • To assess the impact of a 12-week personalized, biomarker-guided supplementation program on inflammatory and immune markers.
  • To evaluate these effects across different age and sex cohorts.

Main Methods:

  • 48 participants were stratified by sex and age (40-69 years), with blood tests at baseline and 12 weeks.
  • Personalized protocols involved micronutrients (vitamin D, omega-3s, B vitamins, zinc, selenium), hormone support, and peptides based on individual biomarker profiles.
  • Primary outcomes measured percent changes in CRP, ferritin, homocysteine, WBC count, and anti-TPO antibodies.

Main Results:

  • CRP decreased by 33-46%, homocysteine by 29-37%, and WBC count by 22-28% across all groups.
  • Ferritin reductions were significant in men (up to 48%), especially older groups.
  • Anti-TPO antibody levels decreased more in women (up to 22%).

Conclusions:

  • The biomarker-guided personalized supplementation protocol effectively reduced key markers of inflammation and immune dysregulation.
  • Findings suggest potential efficacy for precision-based health optimization.
  • Larger randomized controlled trials are needed to confirm these effects.