Related Experiment Video
Updated: Jan 7, 2026
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
1.4K
Linking thyroid dysfunction with chronic kidney disease among Indian patients.
Gayathri Chelamkuri1, Nalugotla Lakshmanna1, Vadlamudi Chandramohan2
1Department of Biochemistry, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Bioinformation
|December 30, 2025
Summary
Chronic kidney disease significantly impacts thyroid function, with 65.56% of patients showing thyroid abnormalities. This highlights the need for clinical attention to thyroid derangements in kidney disease management.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Chronic kidney disease (CKD) is associated with complex metabolic disturbances.
- The pituitary-thyroid axis and peripheral thyroid hormone metabolism can be significantly affected in CKD patients.
- Thyroid dysfunction is a recognized complication in individuals with kidney disease.
Purpose of the Study:
- To investigate the prevalence of thyroid abnormalities in patients diagnosed with chronic kidney disease.
- To examine the relationship between kidney function markers and thyroid biomarkers in CKD patients.
Main Methods:
- A cross-sectional study was conducted involving 90 patients with diagnosed chronic kidney disease.
- Blood parameters including urea, creatinine, and thyroid biomarkers were analyzed.
- Pearson's correlation was used to assess the relationship between serum thyroid-stimulating hormone and estimated glomerular filtration rate.
Main Results:
- A high prevalence of thyroid abnormalities was observed, affecting 65.56% (59 out of 90) of the study participants.
- A significant negative correlation was found between serum thyroid-stimulating hormone levels and estimated glomerular filtration rate (r=-0.04, P=0.001).
- Derangements in thyroid biomarkers were common in the CKD patient group.
Conclusions:
- Thyroid dysfunction is prevalent and clinically relevant in patients with chronic kidney disease.
- These findings underscore the importance of monitoring thyroid function in CKD management.
- Awareness of these thyroid derangements can aid clinicians in providing improved patient care for individuals with kidney disease.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
531
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
531
01:28Chronic Kidney Disease III: Interprofessional Care
316
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
316
01:24Chronic Kidney Disease II: Clinical Manifestations
516
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
516
01:18Chronic Kidney Disease IV: Nursing Management
283
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
283
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
238
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
238
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
158
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
158