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Biological Aging Exhibits an Inverted J-Shaped Relationship with Stress Urinary Incontinence in Women
Lingyun Wei1, Xinfang Cao1, Shuyu Wang1
1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, People's Republic of China.
International Journal of Women'S Health
|December 30, 2025
Summary
Biological aging, measured by PhenoAge and Klemera-Doubal Method, is linked to increased urinary incontinence (UI) risk in women. Interventions targeting biological aging may help prevent UI.
Area of Science:
- Gerontology
- Urology
- Epidemiology
Background:
- Biological aging is a key factor in chronic diseases.
- The connection between biological aging and female urinary incontinence (UI) is not well understood.
- This study investigates the association between biological aging metrics and UI in women.
Purpose of the Study:
- To quantify biological age using PhenoAge (PA), Klemera-Doubal Method (KDM), and Homeostatic Dysregulation (HD).
- To assess the association of these biological age metrics with stress UI (SUI), urgency UI (UUI), and mixed UI (MUI).
Main Methods:
- Cross-sectional study of 8,561 women from NHANES (2005-2010, 2015-2018).
- Outlier exclusion and covariate selection using LASSO regression.
- Multivariable logistic regression and restricted cubic splines (RCS) for association and dose-response analyses.
Main Results:
- PhenoAge (PA) and Klemera-Doubal Method (KDM) showed positive associations with UI.
- Higher quartiles of PA and KDM were linked to increased SUI risk and severity.
- Inverted J-shaped and U-shaped relationships were observed between biological aging metrics and UI types.
Conclusions:
- Biological aging is significantly associated with increased UI risk in women.
- Slowing biological aging could be a potential strategy for UI prevention.
- Further longitudinal studies are needed to confirm causality.
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