Related Experiment Video
Updated: Jan 7, 2026
11:20
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
8.0K
Bone-Targeted Multifunctional Nanoplatform Combining Osteoimmunoregulation and Mild Photothermal Effect to Promote
Junli Yang1, Xudong Xie2, Qiaojian Duan1
1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
ACS Nano
|December 30, 2025
Summary
This study developed a novel nanoplatform that targets bone, reduces inflammation, and uses mild photothermal therapy to enhance bone healing. This approach significantly accelerates bone defect reconstruction and promotes tissue regeneration.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Bone fractures often result in poor healing and an imbalanced osteoimmune microenvironment.
- Current treatments struggle to address the complex interplay of inflammation and impaired bone regeneration.
Purpose of the Study:
- To develop a bone-targeting multifunctional nanoplatform for enhanced bone regeneration.
- To investigate the nanoplatform's ability to modulate the osteoimmune microenvironment and promote osteogenesis.
Main Methods:
- Fabrication of Ag2S/Mg2+-incorporated rhodamine B hydrazide-loaded mesoporous silica nanoparticles (RH@Ag2S@MMSNs) conjugated with alendronate and β-cyclodextrin.
- Evaluation of bone-targeting, pH-responsive biodegradability, anti-inflammatory effects, and photothermal therapy (PTT) capabilities.
- Assessment of mesenchymal stem cell osteogenic differentiation and in vivo bone defect repair using NIR-II imaging.
Main Results:
- The RH@Ag2S@MMSNs nanoplatform demonstrated effective bone targeting and pH-responsive degradation.
- The released rhodamine B hydrazide (RH) scavenged nitric oxide (NO), regulated macrophage polarization, and balanced the immune microenvironment.
- Combined Mg2+ and mild PTT under near-infrared irradiation promoted osteogenic differentiation, significantly accelerating bone defect reconstruction in vivo.
Conclusions:
- The developed nanoplatform integrates anti-inflammation, mild PTT, NIR-II imaging, and osteogenic activities for effective bone regeneration.
- This strategy offers a novel approach for designing bioactive multifunctional platforms to promote bone tissue repair.
Related Concept Videos
01:27Fractures: Bone Repair
4.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
4.9K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K