Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

818
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
818
Neural Regulation01:37

Neural Regulation

43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
Hormonal Regulation01:40

Hormonal Regulation

47.6K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.6K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

1.6K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
1.6K
Neurotransmitters01:31

Neurotransmitters

2.5K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
2.5K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

879
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
879

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study.

BMC medicine·2026
Same author

Admission clinical features associated with disease severity in psittacosis pneumonia: A retrospective study.

Diagnostic microbiology and infectious disease·2026
Same author

Analytical techniques for laboratory testing of HIV: a systematic review.

Journal of microbiological methods·2026
Same author

CYP1B1 as a therapeutic target for S. aureus-induced mammary gland inflammation.

Molecular immunology·2026
Same author

Endocrine regimen and early subclinical atherosclerosis in premenopausal HR+/HER2- breast cancer: real-world evidence and regimen-dependent effects of Sanhuang Decoction.

Frontiers in oncology·2026
Same author

Microbe-enzyme synergistic fermentation enhances tobacco stem cell wall degradation by modulating enzymatic activity and microbial community structure.

Frontiers in bioengineering and biotechnology·2026

Related Experiment Video

Updated: Jan 7, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.7K

Microbiota-gut-brain axis and bile acids-driven neuromodulation.

Taiwei Dong1, Tianyi Zhang1, Huanhuan Wang2

  • 1Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Neural Regeneration Research
|December 30, 2025
PubMed
Summary

Bile acids are key signaling molecules influencing inflammation and metabolism, with roles in neurodegenerative diseases. Understanding their complex "microbiota-bile acids-sex" interactions is crucial for developing precision therapies.

Keywords:
Alzheimer’s diseaseHuntington’s diseaseParkinson’s diseaseamyotrophic lateral sclerosisbile acidscentral nervous systemmicrobiota-gut-brain axisneurodegenerative diseasessexual dimorphismtherapeutics

More Related Videos

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.4K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.2K

Related Experiment Videos

Last Updated: Jan 7, 2026

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.7K
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.4K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.2K

Area of Science:

  • Neuroscience
  • Metabolic Signaling
  • Microbiome Research

Background:

  • Bile acids, traditionally viewed as metabolic byproducts, are now recognized as critical signaling molecules.
  • Dysregulation of bile acids is linked to various neurodegenerative diseases.
  • The microbiota-gut-brain axis plays a significant role in bile acid-mediated neuromodulation.

Purpose of the Study:

  • To explore the multifaceted roles of bile acids in neuroinflammation and metabolism.
  • To elucidate the connection between the gut microbiota, bile acids, and brain pathology.
  • To highlight the impact of sexual dimorphism on bile acid signaling and disease susceptibility.

Main Methods:

  • Review of current literature on bile acid signaling pathways.
  • Analysis of the interplay between microbiota, bile acids, and the central nervous system.
  • Investigation of sex-specific differences in bile acid metabolism and function.

Main Results:

  • Bile acids exhibit context-dependent neuroprotective or neurotoxic effects, acting as a "double-edged sword".
  • The "microbiota-bile acids-brain axis" links peripheral metabolic changes to CNS pathology.
  • Sexual dimorphism is a critical factor in bile acid heterogeneity and disease risk.

Conclusions:

  • A novel "microbiota-bile acids-sex" framework is proposed to understand bile acid complexity.
  • Bile acids represent a promising target for precision therapeutic interventions in neurodegenerative diseases.
  • A systemic, metabolic perspective is advocated over a purely brain-centric view.