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Synovium targeted colchicine therapy using pH responsive nanoparticles.

Syeda Komal Fatima1, Naveed Ahmed1, Kainat Gul2

  • 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

Journal of Biomaterials Science. Polymer Edition
|December 30, 2025
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Summary

This study developed novel Colchicine-EL-100-polymeric nanoparticles for targeted gout treatment, offering sustained, pH-responsive drug release and reduced inflammation. The formulation shows promise for localized gout management with fewer systemic side effects.

Keywords:
Goutcolchicinedrug deliverynanoparticlespH responsivetransdermal

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Area of Science:

  • Nanotechnology
  • Pharmacology
  • Biochemistry

Background:

  • Conventional gout therapies present significant systemic adverse effects, necessitating advanced drug delivery systems.
  • Targeted and sustained therapeutic interventions are crucial for effective gout management.
  • The NLRP3 inflammasome plays a key role in gout pathogenesis, making it a viable therapeutic target.

Purpose of the Study:

  • To formulate and characterize Colchicine-EL-100-polymeric nanoparticles for pH-dependent drug release.
  • To evaluate the efficacy of these nanoparticles in an experimental gout model.
  • To investigate the potential for localized gout treatment with reduced systemic toxicity.

Main Methods:

  • Preparation and optimization of polymeric nanoparticles using Box-Behnken Design.
  • Physicochemical characterization using FTIR, XRD, DSC, and FE-SEM.
  • In vitro release, ex vivo permeation, and in vivo studies in a MSU-induced gout model.

Main Results:

  • Molecular docking indicated favorable binding of colchicine to NLRP3.
  • Optimized nanoparticles demonstrated good physicochemical stability (size, zeta potential, EE%).
  • pH-dependent release was observed, with enhanced release at pH 6.8 and restricted release at pH 7.4.
  • Ex vivo studies confirmed dermal penetration, and in vivo studies showed significant reduction in inflammation and IL-6 levels.

Conclusions:

  • Colchicine-EL-100-polymeric nanoparticles offer a promising platform for sustained and targeted gout therapy.
  • The pH-responsive release mechanism facilitates localized drug delivery.
  • This formulation demonstrates significant therapeutic potential for managing gout with improved safety profile.