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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
First Trimester Maternal Folate and Vitamin B12 Concentrations and Their Associations With First-Trimester Placental
M M Van Vliet1, S Schoenmakers, S P Willemsen
1Departments of Obstetrics and Gynecology (M.M.V.V., S.S., R.P.M.S.-T.), Developmental Biology (M.M.V.V.), Biostatistics (S.P.W.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and School of Biosciences, Sutton Bonnington Campus, University of Nottingham, Leicestershire, United Kingdom (K.D.S.).
None:
(Abstracted from Hum Reprod 2025 ;40(8):1485-1494) Embryonic development relies heavily on 1-carbon metabolism, which is influenced heavily by folate and vitamin B12. Both placental and embryonic and fetal development are affected, and previous research has shown supplementation with folic acid during early pregnancy reduces the prevalence of neural tube defects; some research has also shown that deficiencies in folate and vitamin B12 may be associated with adverse pregnancy outcomes such as preeclampsia and low birth weight.
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