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An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3): 10-Year
Cathalijne C B Post1, Stephanie M de Boer, Melanie E Powell
1Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands (C.C.B.P., S.M.d.B., R.A.N., C.L.C.); Department of Clinical Oncology, Barts Health NHS Trust, London, United Kingdom (M.E.P.); Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia (L.M.); Department of Surgical Sciences and Gynaecology, Città della Salute and S Anna Hospital, Turin, Italy (D.K.); Department of Gynaecologic Oncology, University of Sherbrooke, Sherbrooke, Quebec, Canada (P.B.); Department of Cancer Medicine and Gynaecological Tumours Translational Research Lab, Gustave Roussy Cancer Centre, INSERM U981, Université Paris Saclay, Villejuif, France (A.L.); Department of Medical Oncology, Radboudumc, Nijmegen, the Netherlands (P.B.O.); Department of Clinical Oncology, University College Hospital London, London, United Kingdom (M.M.); Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia (P.K.); Department of Radiation Oncology, Azienda Socio Sanitaria Territoriale, Lecco, Italy (R.D.); Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada (A.F.); Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris, France (C.C.); Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom (H.C.K.); Liverpool Cancer Therapy Centre, Sydney, New South Wales, Australia (V.D.); Department of Obstetrics and Gynaecology, IRCCS San Gerardo dei Tintori, Monza, Italy (A.L.); Department of Gynaecologic Oncology, Centre hospitalier de l'Université de Montréal, Montréal, Quebec, Canada (D.P.); Department of Pathology, Gustave Roussy Cancer Centre, Villejuif, France (C.G.); Department of Gynaecologic Oncology, University Medical Centre Groningen, Groningen, the Netherlands (H.N.); Department of Radiation Oncology, The Clatterbridge Cancer Centre NHS Trust, Liverpool, United Kingdom (K.W.); Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, the Netherlands (I.M.J.); Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, United Kingdom (A.F.); MAASTRO Clinic Radiation Oncology, Maastricht (L.C.H.W.L.); Central Data Management and Trial Coordination, Comprehensive Cancer Centre Netherlands, Rotterdam (J.B.); and Departments of Pathology (A.L.-C., T.B.) and Medical Statistics (H.P.), Leiden University Medical Centre, Leiden, the Netherlands.
Abstract:
(Abstracted from Lancet Oncol 2025;26(10):1370-1381) Fifteen percent to 20% of endometrial cancer patients have a high-risk form of the disease; this classification indicates a higher risk of cancer recurrence and cancer-related death. The standard therapy for high-risk endometrial cancer is pelvic radiotherapy.
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