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Can Chlorhexidine Bathing Reduce Candidozyma auris Shedding?
Gabrielle M Gussin1,2, Raveena D Singh1, Ken Kleinman3
1Division of Infectious Diseases, University of California Irvine School of Medicine, Irvine, California, USA.
Summary
This study shows Candida auris spreads quickly during nursing home care. Chlorhexidine use significantly reduced shedding, indicating its effectiveness in preventing transmission in long-term care settings.
Area of Science:
- Infectious Diseases
- Healthcare Epidemiology
- Antimicrobial Stewardship
Background:
- Candida auris is an emerging multidrug-resistant pathogen causing outbreaks globally.
- Long-term care facilities are vulnerable settings for C. auris transmission due to high-contact patient care.
- Understanding transmission dynamics and effective decolonization strategies is critical.
Purpose of the Study:
- To quantify Candida auris shedding during nursing home caregiving.
- To evaluate the impact of residual chlorhexidine gluconate on C. auris shedding.
- To assess the efficacy of chlorhexidine-based decolonization in reducing transmission risk.
Main Methods:
- Settle plate method used to assess environmental contamination.
- Measured residual chlorhexidine gluconate concentrations on surfaces.
- Correlated chlorhexidine levels with C. auris shedding rates.
Main Results:
- Rapid shedding of Candida auris was observed during nursing home caregiving activities.
- An 80% reduction in shedding was achieved with residual chlorhexidine gluconate concentrations ≥156 µg/mL.
- High-contact care activities identified as key transmission points.
Conclusions:
- Nursing home caregiving facilitates rapid Candida auris transmission.
- Chlorhexidine-based decolonization is effective in mitigating C. auris transmission risk.
- Maintaining adequate chlorhexidine concentrations is crucial for infection control in long-term care.
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