Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.0K
The Thyroid Gland01:23

The Thyroid Gland

6.5K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.5K
The Parathyroid Glands00:59

The Parathyroid Glands

4.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.2K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.6K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.6K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

277
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
277

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equivalence of Anteroposterior and Frog-Leg Lateral Radiographs in Measuring Acetabular Index in Children.

Research square·2026
Same author

The American Thyroid Association Multidisciplinary Consensus Statement on Ambulatory Thyroid Surgery.

Thyroid : official journal of the American Thyroid Association·2026
Same author

A digestive cartridge reduces intestinal injury in a murine model of necrotizing enterocolitis.

PloS one·2026
Same author

Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age.

Pediatrics·2026
Same author

The Landscape of Pediatric Differentiated Thyroid Carcinoma and Predictors of Invasive Disease: A CATC Study.

The Journal of clinical endocrinology and metabolism·2026
Same author

Rethinking race-based interpretation in pediatric densitometry: a scoping review.

JBMR plus·2026
Same journal

Stimulating Thyrotropin Receptor Antibodies Enhance the Expression of Both Thyrotropin Receptors and Insulin-Like Growth Factor 1 Receptors in Fibroblasts.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Mild Thyroid Eye Disease-The Most Common yet the Least Studied Presentation of Thyroid Eye Disease.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

In Memoriam: Lawrence Crane Wood (1935-2026).

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Trends in Management and Outcomes of Pediatric Hyperthyroidism Over Two Decades.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

<i>Retraction Notice:</i> High Iodine Concentration Attenuates <i>RET/PTC3</i> Oncogene Activation in Thyroid Follicular Cells.

Thyroid : official journal of the American Thyroid Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.6K

Thyroid Function After Hemithyroidectomy in Children.

Yamini Adusumelli1, Carter R Petty2, Christine E Cherella3

  • 1Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.

Thyroid : Official Journal of the American Thyroid Association
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Children undergoing hemithyroidectomy face a 27.5% risk of hypothyroidism within five years, often developing in the first year post-surgery. Preoperative TSH levels and TPO antibodies help identify high-risk pediatric patients.

Keywords:
hypothyroidlobectomypediatricsurgery

More Related Videos

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

632
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

768

Related Experiment Videos

Last Updated: Jan 7, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.6K
Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

632
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

768

Area of Science:

  • Pediatric Endocrinology
  • Pediatric Surgery
  • Thyroidology

Background:

  • The incidence and predictive factors for hypothyroidism following hemithyroidectomy in pediatric patients are not well-established.
  • Understanding these risks is crucial for optimizing postoperative care and patient counseling in pediatric thyroid surgery.

Purpose of the Study:

  • To determine the incidence of hypothyroidism after hemithyroidectomy in children.
  • To identify clinical factors associated with an increased risk of postoperative hypothyroidism.

Main Methods:

  • Retrospective cohort study of 136 pediatric patients (<19 years) undergoing hemithyroidectomy.
  • Analysis of postoperative thyroid function and levothyroxine (LT4) treatment status.
  • Utilized univariable/multivariable survival analysis and logistic regression to assess risk factors.

Main Results:

  • The 5-year risk of persistent hypothyroidism or LT4 treatment (PersHypo/LT4) was 27.5%.
  • Preoperative TSH ≥ 2 mIU/L was associated with a significantly higher 5-year risk (58.8% vs. 12.8%).
  • Thyroperoxidase (TPO) antibodies were independently associated with an increased risk of PersHypo/LT4 (OR: 7.37).

Conclusions:

  • Persistent hypothyroidism or LT4 treatment affects over a quarter of children within 5 years of hemithyroidectomy, primarily within the first year.
  • Preoperative TSH levels and TPO antibody status can stratify pediatric patients into low- and high-risk groups for developing hypothyroidism.
  • Findings guide preoperative counseling and postoperative monitoring strategies for pediatric hemithyroidectomy patients.