Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fluid Movement Between Compartments01:18

Fluid Movement Between Compartments

3.6K
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
3.6K
Relative Velocity in Two Dimensions01:11

Relative Velocity in Two Dimensions

8.8K
Relative velocity is the velocity of an object as observed from a particular reference frame, or the velocity of one reference frame with respect to another reference frame. The concept of relative velocity can be used to describe motion in two dimensions. Consider a particle P and two reference frames S and S′. The position of the origin of S′ as measured in S is , the position of P as measured in S′ is , and the position of P as measured in S is , which can be evaluated by utilizing...
8.8K
Velocity and Position by Graphical Method01:34

Velocity and Position by Graphical Method

9.4K
Velocity and position can be calculated from the known function of acceleration as a function of time. The total area under the acceleration-time graph and the velocity-time graph gives the change in velocity and position, respectively. In the case of an airplane, its acceleration is tracked using the inertial navigation system. The pilot provides the input of the airplane's initial position and velocity before takeoff. The inertial navigation system then uses the acceleration data to...
9.4K
Relative Velocity in One Dimension01:10

Relative Velocity in One Dimension

9.6K
The understanding of the concept of reference frames is essential to discuss relative motion in one or more dimensions. When we say that an object has a certain velocity, we must state the velocity with respect to a given reference frame. In most examples, this reference frame has been Earth. For instance, if a statement reads that a person is sitting in a train moving at 10 m/s east, then it implies that the person on the train is moving relative to the surface of Earth at this velocity,...
9.6K
Drag Force and Terminal Speed01:18

Drag Force and Terminal Speed

3.2K
An interesting force in everyday life is the force of drag on an object when it is moving in a fluid. Like friction, the drag force always opposes the motion of an object. Unlike simple friction, the drag force is proportional to some function of the velocity of the object in that fluid. This functionality is complicated and depends upon the shape of the object, its size, its velocity, and the fluid it is in. For most large objects, such as cyclists, cars, and baseballs, that are not moving too...
3.2K
Development of Blood Vessels01:07

Development of Blood Vessels

1.3K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinically translatable ultrasound localization microscopy reveals cerebrovascular remodelling and prognosis in patients with traumatic brain injury.

Nature biomedical engineering·2026
Same author

Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging.

Research square·2026
Same author

Distinct developmental trajectories of externally and internally generated hippocampal sequences and assemblies.

Current biology : CB·2026
Same author

Focused ultrasound opens the blood-brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Revisiting XDoppler estimator for high spatiotemporal resolution volumetric axial velocity measurement using row-column arrays.

Ultrasonics·2026
Same author

In vivo microvascular flow quantification in the mouse brain using row-column ultrasound localization microscopy and directed graph analysis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

Single-nucleotide RNA m<sup>6</sup>A mapping in bovine preimplantation development reveals site-specific regulation of RPL12 at zygotic genome activation.

Cell reports·2026
Same journal

M4-ipRGCs regulate contrast sensitivity in vision.

Cell reports·2026
Same journal

Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site.

Cell reports·2026
Same journal

Structural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation.

Cell reports·2026
Same journal

Physical interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression.

Cell reports·2026
Same journal

An IGF2BP3-dependent metabolic circuit governs macrophage recruitment and immunosuppression in glioblastoma.

Cell reports·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.6K

A vascular code for speed in the spatial navigation system.

Felipe Cybis Pereira1, Sebastian H Castedo2, Samuel Le Meur-Diebolt1

  • 1Physics for Medicine Paris, INSERM, ESPCI Paris, CNRS, PSL Research University, 75015 Paris, France; Iconeus, 75014 Paris, France.

Cell Reports
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Researchers used functional ultrasound (fUS) imaging to study brain blood flow during rat navigation. They found that cerebral blood volume (CBV) changes accurately reflect locomotion speed, revealing key vascular dynamics in the hippocampus.

Keywords:
CP: neuroscienceanimal speedcerebral blood volumecontinuous attractor networkfreely movingfunctional ultrasound imaginghippocampuslocomotionpath integrationspatial navigation

More Related Videos

Virtual Reality Experiments with Physiological Measures
07:09

Virtual Reality Experiments with Physiological Measures

Published on: August 29, 2018

13.2K
Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind
09:01

Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind

Published on: March 27, 2013

14.9K

Related Experiment Videos

Last Updated: Jan 7, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.6K
Virtual Reality Experiments with Physiological Measures
07:09

Virtual Reality Experiments with Physiological Measures

Published on: August 29, 2018

13.2K
Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind
09:01

Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind

Published on: March 27, 2013

14.9K

Area of Science:

  • Neuroscience
  • Physiology
  • Biomedical Engineering

Background:

  • Understanding the brain's vascular dynamics during spatial navigation is crucial.
  • Previous research has limited insight into these processes during naturalistic behavior.

Purpose of the Study:

  • To investigate cerebral blood volume (CBV) changes in the hippocampus during free exploration in rats.
  • To explore the relationship between CBV, locomotion speed, and information flow in navigation circuits.

Main Methods:

  • Functional ultrasound (fUS) imaging was employed to monitor high-resolution CBV changes in freely moving rats.
  • Lagged general linear modeling and multivariate decoding were used to analyze neurovascular coupling and information encoding.

Main Results:

  • CBV showed strong correlations with animal speed across hippocampal-parahippocampal regions.
  • Hierarchical information flow was identified from the thalamus to parahippocampal cortex and hippocampal subfields.
  • CBV signals accurately encoded locomotion speed, with slow oscillations linked to exploratory behavior.

Conclusions:

  • A hemodynamic signature for speed representation, linked to energy demands in neural networks, was revealed.
  • fUS imaging is established as a powerful tool for studying the neurovascular basis of navigation.