Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Transcriptomic Analysis Reveals That EREG-Driven TME Crosstalk Defines Anti-EGFR Response in Colorectal Cancer.

Cancer medicine·2026
Same author

Mitochondrial inhibition enhances the sensitivity of pancreatic ductal adenocarcinoma cells to oncolytic adenovirus.

Molecular therapy. Oncology·2026
Same author

P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death.

Anticancer research·2026
Same author

Localized cystic dilatation of the intrahepatic bile ducts as a distinct subtype of Caroli disease: a case report.

Journal of medical case reports·2026
Same author

Turning pancreatic cancer from cold to hot: the promise of a p53-expressing oncolytic adenovirus (OBP-702).

International journal of clinical oncology·2026
Same author

Collagen depletion by pirfenidone enhances antitumor effect of oncolytic adenovirus against peritoneal metastases of gastric cancer.

Molecular therapy. Oncology·2026

Related Experiment Video

Updated: Jul 24, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
07:52

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts

Published on: April 26, 2018

9.4K

Near-infrared Photoimmunotherapy Targeting High-risk Human Neuroblastoma Cells Expressing GD2.

Hiroshi Nouso1, Hiroshi Tazawa2,3, Terutaka Tanimoto1

  • 1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Anticancer Research
|December 30, 2025
PubMed
Summary

GD2-targeted near-infrared photoimmunotherapy (NIR-PIT) effectively reduced high-risk neuroblastoma (NB) tumor growth. This novel immunotherapy shows promise for treating GD2-expressing NB tumors where other treatments are insufficient.

Keywords:
GD2IR700Neuroblastomanear-infrared photoimmunotherapy

More Related Videos

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.7K
Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

2.9K

Related Experiment Videos

Last Updated: Jul 24, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
07:52

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts

Published on: April 26, 2018

9.4K
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.7K
Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

2.9K

Area of Science:

  • Oncology
  • Immunotherapy
  • Biotechnology

Background:

  • Neuroblastoma (NB) is a common childhood cancer with a poor prognosis for high-risk patients.
  • Current immunotherapies, like anti-GD2 antibodies, have insufficient efficacy for high-risk NB.
  • Near-infrared photoimmunotherapy (NIR-PIT) offers a targeted approach to cancer treatment.

Purpose of the Study:

  • To investigate the therapeutic potential of GD2-targeted NIR-PIT against human neuroblastoma cells.
  • To evaluate the efficacy of GD2-targeted NIR-PIT in preclinical models of high-risk NB.

Main Methods:

  • GD2 expression was confirmed on high-risk NB cell lines (CHP-134, LA-N-5, IMR-32) using flow cytometry.
  • GD2-targeted NIR-PIT was synthesized using anti-GD2 antibody and IR700.
  • Cytotoxicity and in vivo antitumor effects were assessed in cell cultures, tumor spheres, and xenograft models.

Main Results:

  • GD2 was expressed on high-risk NB cells but not on non-high-risk cells (SK-N-SH).
  • GD2-targeted NIR-PIT significantly reduced the viability of GD2-positive NB cells.
  • NIR-PIT inhibited tumor growth in subcutaneous xenograft models and reduced tumor sphere volume.

Conclusions:

  • GD2-targeted NIR-PIT demonstrates significant antitumor activity against GD2-positive neuroblastoma.
  • This approach is a promising therapeutic strategy for high-risk neuroblastoma.
  • Further research into GD2-targeted NIR-PIT for NB treatment is warranted.