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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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MUTATIONAL STATUS AND TREATMENT EFFICACY IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA

I S Dyagil1, D A Bazyka1, I V Kirieieva1

  • 1State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 30, 2025
PubMed
Summary

Resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) is often caused by BCR::ABL1 gene mutations. Personalized therapy based on mutation status, utilizing newer TKIs like ponatinib and asciminib, is crucial for effective CML treatment.

Keywords:
BCR::ABL1T315ImutationTKI resistanceasciminibchronicmyeloidleukemiadasatinibimatinibmutation statusnilotinibponatinibtyrosine kinase inhibitors (TKIs)

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