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X-Ray Structures, Intermolecular Interactions, and Structural Transformations of Dihydroquercetin Solvates and
Xin Meng1, Yao Zou1, Shiying Yang1
1Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Pharmaceutics
|December 31, 2025
Summary
Dihydroquercetin exhibits diverse biological activities. This research identifies novel solid forms and solvates, enhancing understanding of its physicochemical properties and polymorphism for dietary supplements and functional foods.
Area of Science:
- Solid-state chemistry
- Crystallography
- Materials science
Background:
- Dihydroquercetin is recognized for its extensive biological activities.
- It is a significant ingredient in functional foods and dietary supplements.
- Understanding its solid-state properties is crucial for formulation.
Purpose of the Study:
- To discover and characterize novel pure solid forms of dihydroquercetin.
- To investigate the physicochemical properties and polymorphism of dihydroquercetin.
- To elucidate the crystal structures and intermolecular interactions of its solvates.
Main Methods:
- Systematic screening and preparation of dihydroquercetin solid forms.
- Characterization using single-crystal and powder X-ray diffraction, DSC, TG, and FT-IR.
- Analysis of intermolecular forces, void maps, and energy frameworks.
Main Results:
- Five novel solvates (monohydrate, sesquihydrate, dihydrate, ACN solvate) and one solvent-free phase were identified.
- Crystal structures of the five solvates were elucidated for the first time.
- O···H interactions were found to be the dominant intermolecular forces.
Conclusions:
- Dihydroquercetin forms multiple solvates and a solvent-free phase.
- The crystal structures and intermolecular interactions were thoroughly characterized.
- Hydrogen bonding plays a critical role in the stability of dihydroquercetin solid forms.
Keywords:
crystal structuredihydroquercetinenergy frameworkshirshfeld surfacephysical characterizationpolymorphssolvatesMore Related Videos
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