Improved Dissolution of Poorly Water-Soluble Rutin via Solid Dispersion Prepared Using a Fluid-Bed Coating System

Area of Science:

• Pharmacology
• Materials Science

Background:

• Rutin, a potent antioxidant and anti-inflammatory agent, has limited use due to poor solubility and bioavailability.
• Developing effective delivery systems is crucial for rutin's therapeutic potential.

Purpose of the Study:

• To enhance rutin's dissolution and bioavailability using solid dispersions (SDs) prepared via fluid-bed coating.
• To formulate these SDs into stable and effective tablet dosage forms.

Main Methods:

• Rutin was spray-coated onto various carriers using a fluid-bed system.
• Lactose monohydrate was identified as the optimal carrier, with a 1:10 rutin-to-lactose ratio.
• Solid dispersions were characterized using PXRD, DSC, SEM, and FT-IR, and formulated into tablets.

Main Results:

• Lactose monohydrate significantly enhanced rutin dissolution, achieving complete release in 15 minutes.
• Characterization confirmed reduced crystallinity and improved adsorption of rutin onto lactose monohydrate.
• Optimized tablets showed enhanced dissolution and stability over 6 months.

Conclusions:

• Fluid-bed coating is an effective method for creating rutin solid dispersions.
• This approach can improve the dissolution of rutin and potentially other natural polyphenols.