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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Drug Delivery: Parenteral Route01:29

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PLGA-Based Co-Delivery Nanoformulations: Overview, Strategies, and Recent Advances.

Magdalena M Stevanović1, Kun Qian2, Lin Huang3,4

  • 1Group for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, 11000 Belgrade, Serbia.

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Summary
This summary is machine-generated.

Poly (lactic-co-glycolic acid) (PLGA) nanoformulations enable advanced drug co-delivery for complex diseases. This review integrates design, mechanisms, and translation, highlighting PLGA

Keywords:
classification of co-delivery typesclinical translation and regulatory considerationsdrug releasefabrication and modificationnanoparticles

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Polymer Chemistry

Background:

  • Poly (lactic-co-glycolic acid) (PLGA) is a biocompatible and biodegradable copolymer extensively utilized in medical and pharmaceutical applications.
  • Its properties make PLGA a versatile platform for nanoscale drug delivery systems.
  • Recent advancements focus on PLGA-based nanoformulations for co-delivery applications.

Purpose of the Study:

  • To provide a comprehensive review of PLGA-based co-delivery nanoformulations.
  • To analyze design strategies, functional mechanisms, and translational potential.
  • To bridge the gap between PLGA fundamentals and co-delivery approaches for precision therapeutics.

Main Methods:

  • Review of current literature on PLGA-based co-delivery systems.
  • Analysis of fabrication methods, nanocarrier design, and scale-up approaches.
  • Discussion of co-delivery types (drug-drug, drug-gene, gene-gene, multi-modal), release mechanisms, and surface modifications.

Main Results:

  • PLGA co-delivery systems demonstrate synergistic therapeutic outcomes, particularly for cancer and complex diseases.
  • Integrated analysis reveals critical links between design strategies and translational requirements.
  • Emerging trends and future perspectives in PLGA-based nanomedicine are identified.

Conclusions:

  • PLGA-based co-delivery strategies are pivotal for advancing precision therapeutics.
  • These platforms possess significant clinical and translational potential.
  • Addressing challenges in reproducibility, manufacturing, and regulation is key for future development.