Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Beyond proteolysis: rational modification of mucin-derived peptidomimetics with enhanced metal-mediated antimicrobial activity.

RSC advances·2026

Same author

Diversity and Multi-Target Potential of Pyrazole, Imidazole or Triazole Derivatives in Modern Anticancer Therapy.

International journal of molecular sciences·2026

Same author

New Oxicam Derivatives-Studies of Membrane Interactions, Cytotoxicity, Cyclooxygenase Inhibition and Molecular Docking.

Membranes·2026

Same author

Anticancer Activity of Microbial Biosurfactants Amphisin and Viscosinamide Against Melanoma Cells.

Molecules (Basel, Switzerland)·2026

Same author

Advances in Lycopene Production: From Natural Sources to Microbial Synthesis Using <i>Yarrowia lipolytica</i>.

Molecules (Basel, Switzerland)·2025

Same author

The Chelating Abilities of Tertiary Amines with N-O-Donors Towards Cu(II) Ions and the Catalytic Properties of the Resulting Complexes.

Molecules (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

New Dimethylpyridine-3-Carboxamide Derivatives as MMP-13 Inhibitors with Anticancer Activity.

Remigiusz Płaczek¹, Tomasz Janek², Małgorzata Strzelecka³

¹Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

Molecules (Basel, Switzerland)

|December 31, 2025

Summary

New MMP-13 inhibitors were synthesized and tested. These compounds show selective inhibition of matrix metalloproteinase 13 (MMP-13) and potential anticancer activity, offering promising therapeutic avenues.

Keywords:

MMP-13 inhibitors anticancer activity dimethylpyridine-3-carboxamide derivatives

More Related Videos

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Related Experiment Videos

Last Updated: Jun 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Area of Science:

Medicinal Chemistry
Biochemistry
Computational Chemistry

Background:

Matrix metalloproteinase 13 (MMP-13) plays a role in various diseases.
Developing selective MMP-13 inhibitors is crucial for targeted therapies.

Purpose of the Study:

Design, synthesize, and evaluate novel dimethylpyridine-3-carboxamide derivatives as selective MMP-13 inhibitors.
Investigate their binding interactions, plasma transport properties, and in vitro biological activity.

Main Methods:

Synthesis and structural confirmation (FT-IR, NMR, HR-MS).
Fluorescence spectroscopy for human serum albumin interaction.
Density functional theory (DFT) for electronic properties.
Molecular docking and dynamics simulations for binding analysis.
Biological evaluation for MMP-13 inhibition and cytotoxicity.

Main Results:

Synthesized compounds confirmed by spectroscopic and mass spectrometry methods.
Compounds showed stable interactions with MMP-13's S1 pocket via hydrogen bonds and π-stacking.
Demonstrated selective inhibition of MMP-13 over MMP-8.
Exhibited cytotoxic activity against cancer cell lines.
Fluorescence studies provided insights into plasma transport properties.

Conclusions:

The designed dimethylpyridine-3-carboxamide derivatives are potent and selective MMP-13 inhibitors.
These compounds possess favorable binding characteristics and potential for anticancer applications.
Further investigation into their therapeutic potential is warranted.