Protocol and Statistical Analysis Plan for a Multicenter Randomized Trial of Ketamine vs Etomidate for Emergency...

Stephanie C DeMasi¹, Brant Imhoff¹, Ariel A Lewis¹+38

• ¹From the Department of Emergency Medicine (S. C. D., G. W. W. V. S., A. J. L., W. H. S., and J. H. H.), the Department of Biostatistics (B. I. and L. W.), the Vanderbilt Institute for Clinical and Translational Research (A. A. L., B. D. L., T. L. I., T. W. R., W. H. S., J. D. C., and M. W. S.), the Division of Allergy, Pulmonary, and Critical Care Medicine (K.P. S., A. L. M., T. W. R., J. D. C., and M. W. S.), the Department of Pharmacy (K. C. S.), Vanderbilt University Medical Center, the Geriatric Research, Education, and Clinical Center (J. H. H.), Tennessee Valley Healthcare System, Nashville, TN; the Department of Emergency Medicine (B. E. D., M. E.P., A. E. R., and G. K. C.), the Division of Pulmonary, Allergy, and Critical Care Medicine (M. E.P. and G. K. C.), Department of Medicine, Hennepin County Medical Center, Minneapolis, MN; the Section of Pulmonary, Critical Care, Allergy and Immunologic Disease (K. W. G., J. A.P., and J. M. C.), Department of Medicine, the Department of Anesthesiology-Critical Care (J.P. G.), the Department of Emergency Medicine (J.P. G. and B. R.), Wake Forest School of Medicine, Winston-Salem, NC; the Department of Emergency Medicine (A. A. G., S. A. T., D. R.-A., and C. W.), the Department of Anesthesiology (L. J. S., J. C. B., and D. J. D.), University of Colorado School of Medicine; the Division of Pulmonary Sciences and Critical Care Medicine (N. R. A. and C. H.), Department of Medicine, University of Colorado Anschutz Medical Center, Aurora; the Department of Emergency Medicine (S. A. T. and C. L.), the Department of Anesthesiology (L. J. S.), Denver Health Medical Center (B. G.), Denver, CO; the Division of Pulmonary, Allergy and Critical Care Medicine (D. W. R., M. R. W., and S. G.), Department of Medicine, the Department of Emergency Medicine (M. R. W. and L. L. B.), University of Alabama at Birmingham, the Pulmonary Section (D. W. R.), Birmingham Veteran's Affairs Medical Center (J. M.), Birmingham, AL.