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Structure and Function of Platelets

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Updated: Jan 7, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Cold-stored platelets: revisiting assumptions and addressing variability to support implementation.

Janhavi Mahajan^1,2, Matthew P Padula², Denese C Marks^1,3

¹Research and Development, Australian Red Cross Lifeblood, Alexandria, NSW, Australia.

Frontiers in Medicine

|December 31, 2025

Summary

This summary is machine-generated.

Cold storage of platelets can extend shelf life to 21 days, offering a viable alternative to room temperature storage. However, variations in processing methods may impact clinical outcomes, requiring further research and standardization for effective platelet transfusion.

Keywords:

cold-stored platelet refrigeration storage transfusion

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Published on: March 19, 2016

Area of Science:

Transfusion Medicine
Hematology

Background:

Platelets are crucial for hemostasis and conventionally stored at room temperature (RT), limiting shelf life to 5-7 days due to bacterial risk.
Cold storage (2-6°C) of platelets offers extended shelf life up to 21 days and is being increasingly implemented globally.

Purpose of the Study:

To review assumptions regarding cold-stored platelets.
To highlight the impact of processing variations on platelet characteristics and clinical outcomes.
To inform future research and best practices for cold-stored platelet implementation.

Main Methods:

Literature review of historical and current research on cold-stored platelets.
Analysis of variations in platelet processing from collection to transfusion.
Discussion of potential effects of these variations on post-transfusion clinical outcomes.

Main Results:

Cold storage significantly extends platelet shelf life compared to RT storage.
Variations in collection platforms, storage solutions, and component modifications can alter platelet characteristics during cold storage.
The impact of these processing variations on clinical outcomes is often overlooked.

Conclusions:

Standardization of processing methods for cold-stored platelets is necessary.
Further research is needed to understand how processing variations affect clinical efficacy and safety.
Addressing these variables is crucial for optimizing cold-stored platelet utilization in clinical practice.