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Updated: Jan 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Maternal Psychotherapy Addressing Generational Stress is Associated with Lower Preterm Birth Risk: The Pforzheim

Gerlinde As Metz1,2, Tanzi D Hoover1, Rupert Linder3

  • 1Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada.

Women'S Health Reports (New Rochelle, N.Y.)
|December 31, 2025
PubMed
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This summary is machine-generated.

Psychotherapy during pregnancy reduced cesarean sections and preterm births, leading to healthier newborns. This approach supports maternal well-being and improves birth outcomes for both mother and child.

Area of Science:

  • Perinatal Psychology
  • Maternal-Fetal Medicine
  • Psychosomatic Medicine

Background:

  • Maternal distress is a significant risk factor for adverse pregnancy outcomes.
  • Inter- and transgenerational stress can negatively impact maternal and infant health.
  • Psychotherapy offers a potential intervention to mitigate these risks and build resilience.

Purpose of the Study:

  • To examine the association between integrated, personalized psychotherapy and pregnancy/birth outcomes.
  • To assess the impact of psychotherapy focused on inter- and transgenerational stress on maternal and infant health.
  • To compare outcomes in women receiving psychotherapy with regional standard care data.

Main Methods:

  • A study involving 239 women and their babies at a specialized German clinic (2004-2012).
Keywords:
birth outcomebirth weightcesarean sectionintergenerationalmaternal healthmental healthnewborn healthpremature birthpsychosomaticsalutogenesissocial supportstresstransgenerational

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  • Pregnant women received routine gynecological care plus complementary psychotherapy (system-oriented, solution-focused, salutogenesis, couple therapy).
  • Data were compared with regional birth records from Pforzheim (n=18,690) and Baden-Württemberg (n=815,832).

    • Main Results:

    • Psychotherapy was linked to lower rates of cesarean sections and vaginal surgical procedures.
    • Women receiving psychotherapy had a higher likelihood of spontaneous birth (18.2%) and lower preterm birth rates (2.2% vs. 9.0%).
    • Infants born to mothers in the psychotherapy group had improved anthropometric measures (higher weight, taller, larger head circumference).

    Conclusions:

    • Psychotherapeutic counseling integrated with standard gynecological care is associated with improved pregnancy duration, birth mode, and infant birth weight.
    • Psychotherapy during pregnancy appears to be a safe and effective preventive approach.
    • These findings highlight psychotherapy's role in supporting maternal well-being and promoting healthier newborn outcomes.