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Primary Intracranial Sarcomatoid Yolk Sac Tumor With Unique Histology: A Case Report
Jessica A Ortega-Balderas1, Hayde S Ramos-Marrero1, Raquel Garza-Guajardo1
1Department of Anatomical Pathology and Cytopathology, University Hospital "Dr. José Eleuterio González", Monterrey, Nuevo Leon, Mexico.
Case Reports in Pathology
|December 31, 2025
Summary
Primary intracranial yolk sac tumors (YSTs) are rare. This case highlights an unusual sarcomatoid YST, emphasizing YSTs in midline mass differential diagnoses.
Area of Science:
- Neuro-oncology
- Pathology
- Rare Tumors
Background:
- Primary intracranial yolk sac tumors (YSTs) are exceptionally rare.
- Typical histological features of intracranial YSTs are documented, but unusual presentations exist.
Purpose of the Study:
- To report a unique case of primary intracranial pure yolk sac tumor (YST).
- To describe the sarcomatoid morphology in an intra-axial YST.
- To underscore the importance of considering YSTs in the differential diagnosis of midline intracranial masses.
Main Methods:
- Case report of a 20-year-old male patient.
- Histopathological analysis of an intra-axial brain tumor.
- Review of relevant literature on primary intracranial YSTs.
Main Results:
- A pure primary intracranial YST with sarcomatoid morphology was identified.
- The tumor was intra-axial and presented in a young adult male.
- This represents the first reported case of a pure primary intracranial YST with sarcomatoid histology.
Conclusions:
- Primary intracranial YSTs can exhibit uncommon histological patterns, such as sarcomatoid morphology.
- Yolk sac tumors should be included in the differential diagnosis for midline brain masses.
- This case expands the understanding of the histological variability of primary intracranial YSTs.
