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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
242

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Kidney disease impairs tendon function in rats.

Christopher M T Hayden1,2, Natalie K Gilmore1,2, Benjamin Osipov3

  • 1Molecular Cellular and Integrative Physiology Graduate Group, University of California Davis, Davis, California, USA.

The Journal of Physiology
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) weakens tendons, increasing rupture risk. This study shows CKD impairs tendon strength and mechanics in a rat model, providing the first direct evidence of this link.

Keywords:
adeninebone–mineral disordermechanicsmusclerupture

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Area of Science:

  • Nephrology
  • Orthopedics
  • Biomedical Engineering

Background:

  • Chronic kidney disease (CKD) is associated with musculoskeletal issues, including bone and muscle wasting.
  • Case reports suggest a link between CKD and spontaneous tendon ruptures, but mechanistic studies are lacking.

Purpose of the Study:

  • To investigate the impact of CKD on tendon mechanics using an established rat model.
  • To determine if kidney disease alters tendon strength and failure properties.

Main Methods:

  • Male and female Sprague-Dawley rats were divided into control and adenine-induced CKD groups.
  • Achilles and tibialis anterior tendons were analyzed for maximum tensile load, failure stress, modulus, and cross-sectional area.
  • Biochemical markers (creatinine, BUN) and muscle/bone strength were also assessed.

Main Results:

  • Adenine-induced CKD confirmed by elevated creatinine and BUN.
  • Tibialis anterior tendon failure stress was 24% lower in CKD rats.
  • Plantar flexor strength decreased by 13% and femur yield force by 41% (males).
  • Female rats with CKD showed a 25% decrease in Achilles tendon failure stress.

Conclusions:

  • This study provides the first direct experimental evidence that CKD impairs tendon mechanical properties.
  • The findings establish a comprehensive multitissue rat model for studying CKD-related tendon pathology.
  • Further research can explore mechanisms and potential interventions for CKD-associated tendon dysfunction.