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Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution.

John Dingus1, Duck-Kyun Yoo1, Sachin Kumar1

  • 1Department of Medicine, Division of Allergy and Clinical Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT, and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Cell Reports
|December 31, 2025
PubMed
Summary

Wuhan strain mRNA vaccines train the immune system to anticipate future severe acute respiratory syndrome coronavirus 2 variants. Antibodies generated show broad neutralization against Omicron, highlighting a strategy for future vaccine development.

Keywords:
CP: immunologyIGHV3-53SARS-CoV-2SHMantibodyanticipatory breadthgermlineimmune escapeneutralization breadthsomatic hypermutationvaccine

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