Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

561
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
561
Factors Affecting Illness01:18

Factors Affecting Illness

5.0K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Three Developmental Domains01:29

Three Developmental Domains

911
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
911
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

740
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
740
Erikson's Theory on Socioemotional Development during Adulthood01:27

Erikson's Theory on Socioemotional Development during Adulthood

744
Erik Erikson's theory of psychosocial development outlines a series of stages through which individuals progress across the lifespan. Each stage involves a psychosocial conflict that significantly influences personal growth and well-being. Three key stages — intimacy versus isolation, generativity versus stagnation, and integrity versus despair — highlight the developmental challenges faced in adulthood.
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
744

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging.

bioRxiv : the preprint server for biology·2026
Same author

Slowed Gompertzian ageing in long-lived C. elegans results from expansion of decrepitude, not decelerated ageing.

Nature communications·2026
Same author

A hierarchy of causes of death in senescent C. elegans.

npj aging·2026
Same author

The Strehler-Mildvan mortality correlation arises from changes in the variability of ageing.

bioRxiv : the preprint server for biology·2026
Same author

Outcomes of a five-year quality improvement project to improve coding accuracy for children's spinal procedures.

British journal of neurosurgery·2026
Same author

Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans.

Communications biology·2025
Same journal

Senescent cells accumulate lipid droplets.

Aging·2026
Same journal

Short-term responsiveness of DNA methylation-based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing <i>Bifidobacterium longum</i> BB536: an exploratory randomized controlled trial.

Aging·2026
Same journal

Hormonal dimorphism in sarcopenia disease.

Aging·2026
Same journal

The multifaceted inducers of cellular senescence.

Aging·2026
Same journal

Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.

Aging·2026
Same journal

Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.

Aging·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.7K

Aging as a multifactorial disorder with two stages.

David Gems1, Alexander Carver1, Yuan Zhao2

  • 1Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.

Aging
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Aging involves a two-stage process where early-life injuries accumulate and are later exacerbated by genetic factors, leading to late-life diseases. This model explains the development of age-related pathologies like cancer and osteoarthritis.

Keywords:
C. elegansagingdiseasehyperfunctionmultifactorial model

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.1K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.7K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.1K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Area of Science:

  • Gerontology and molecular biology
  • Pathology and disease mechanisms
  • Evolutionary biology

Background:

  • Aging (senescence) is marked by diverse pathologies and diseases, contributing to mortality.
  • Major age-related diseases (e.g., cardiovascular disease, cancer, COPD) are multifactorial, arising from complex etiological interactions.
  • Understanding the interplay of aging determinants is crucial for explaining late-life disease development.

Purpose of the Study:

  • To propose a general framework for how aging determinants interact to cause late-life diseases.
  • To illustrate this framework using studies from the nematode *Caenorhabditis elegans*.
  • To elucidate the two-stage process underlying senescence and pathology formation.

Main Methods:

  • Conceptual modeling based on existing research, particularly in *Caenorhabditis elegans*.
  • Analysis of distinct etiological phases contributing to aging and disease.
  • Identification of key mechanisms, including injury accumulation, containment failure, and gene action.

Main Results:

  • Senescence is proposed as a two-stage process: early-life insults and late-life consequences of wild-type gene action.
  • Early-life disruptions (infection, injury, mutation) lead to contained latent injuries.
  • In later life, loss of containment allows latent injuries to develop into pathologies like osteoarthritis, cancer, and reactivated infections.

Conclusions:

  • Aging involves the accumulation of latent injuries that are "seeded" before senescence.
  • Programmatic changes during aging lead to the loss of containment of these latent injuries.
  • This loss of containment facilitates the germination of latent injuries into diverse late-life diseases.