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Comprehensive pharmacological insights into Glaucocalyxin A: Mechanisms and therapeutic potential
Yizhou Zheng1, Lin Liu2, Lilong Liu3
1Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China; Department of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Abstract:
Glaucocalyxin A (GLA) is an ent-kauranoid diterpenoid isolated from Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara. As a promising compound with significant therapeutic potential, GLA has garnered attention for its diverse range of biological activities. These include anti-tumor, anti-inflammatory, and anti-fibrotic effects, as well as cardioprotective effects. The results of network pharmacology and molecular docking predict that GLA may regulate the PI3K/Akt and p53 signaling pathways by interacting with targets including CHEK1, MDM2, and CDK2. Among these, PTGS2 is proposed as the most promising candidate for a direct target, a hypothesis that necessitates further experimental validation. This review comprehensively discusses the development potential of GLA based on its biological activities, molecular targets, signaling pathways, and future translational prospects.
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