Bone microenvironments-regulated biomaterials boost osteonecrosis therapy
Hang Dong1, Tongtong Zhu1, Yirong Sun2
1Department of Traumatic Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China.
Biomaterials
|December 31, 2025
Summary
This review explores biomaterial strategies for treating osteonecrosis (bone death), focusing on enhancing bone regeneration and vascularization while controlling immune responses and bone resorption.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Regenerative Medicine
Background:
- Osteonecrosis involves vascular damage, bone cell death, and abnormal bone remodeling, leading to joint deterioration and pain.
- Current treatments like bone grafting face limitations due to autologous bone scarcity.
- Advanced biomaterials offer potential for improved osteonecrosis treatment.
Purpose of the Study:
- To systematically review current biomaterial-based strategies for osteonecrosis treatment.
- To highlight innovative approaches for vascular regeneration and osteogenesis.
- To discuss biomaterial fabrication, mechanisms, and future trends in bioactive materials.
Main Methods:
- Systematic review of literature on biomaterials for osteonecrosis.
- Analysis of strategies enhancing vascularization, osteogenesis, and immune modulation.
- Overview of biomaterial fabrication and tissue regeneration mechanisms.
Main Results:
- Biomaterials can promote vascular regeneration and bone formation.
- Strategies exist to suppress osteoclast activity and modulate immune responses.
- Fabrication methods and bioactive material development are advancing.
Conclusions:
- Biomaterial-based therapies show promise for osteonecrosis treatment.
- Future research should focus on next-generation biomaterials for enhanced tissue regeneration.
- Multifunctional biomaterials are key to addressing complex osteonecrosis pathology.
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