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Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

494
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
494

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Related Experiment Video

Updated: Jan 7, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

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Mapping Regional Changes in Multiple-Timepoint Hyperpolarized Gas Ventilation Images and Validation by Radiologist

Ummul Afia Shammi1, Talissa Altes2, Cody Thornburgh2

  • 1Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois, USA, uic.edu.

International Journal of Biomedical Imaging
|January 1, 2026
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Summary
This summary is machine-generated.

Hyperpolarized gas MRI algorithms accurately map regional ventilation changes in lung disease patients. These maps align with radiologist assessments, aiding clinical evaluation of treatment effectiveness.

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Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Computational Biology

Background:

  • Hyperpolarized gas (HPG) magnetic resonance imaging (MRI) is an FDA-approved technique for assessing lung function and gas distribution in adults and children.
  • This advanced imaging modality provides novel insights into respiratory system dynamics.

Purpose of the Study:

  • To develop and validate an algorithm for generating regional ventilation change maps in patients with asthma, cystic fibrosis, and COPD.
  • To compare these quantitative maps against qualitative radiologist assessments to determine accuracy and clinical utility.

Main Methods:

  • Hyperpolarized 3He MRI was performed on 20 patients (9 asthmatics, 6 cystic fibrosis, 5 COPD) before and after treatment.
  • Image processing involved N4ITK bias correction, smoothing, normalization, and registration for creating difference maps.
  • Radiologists evaluated maps using a rubric assessing volume discrepancy and its causes.

Main Results:

  • The algorithm-generated change maps showed good agreement with radiologist visual evaluations in 75% of cases (15/20).
  • Minor to no volume disparities were observed in most cases, with only a few showing moderate to large differences.
  • The technique identified short-term improvements (STI) in ventilation.

Conclusions:

  • Regional ventilation change maps derived from HPG MRI are congruent with expert visual assessment.
  • This quantitative approach shows promise as a valuable tool for longitudinal monitoring of ventilation changes in respiratory diseases.